The problem of pathogens acquiring resistance to the antimicrobial drugs that we have is a known issue. While we scramble to find new, improved drugs against these superbugs, researchers like Pamela Yeh are looking into how to use combination of the drugs we already have. Here she talks about using 2-, 3- and multi drug combinations and what the implications are in the field of anti-microbial resistance.
Alejandra Rodrı ́guez-Verdug, Natalie Lozano-Huntelman, Mauricio Cruz-Loya, Van Savage, Pamela Yeh. Compounding Effects of Climate Warming and Antibiotic Resistance. https://doi.org/10.1016/j.isci.2020.101024
Pamela Yeh, Ariane I Tschumi & Roy Kishony. Functional classification of drugs by properties of their pairwise interactions. doi:10.1038/ng1755
Tobias Bollenbach, Selwyn Quan, Remy Chait, and Roy Kishony. Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions. DOI 10.1016/j.cell.2009.10.025